Mir155^tm1Rsky
Targeted Allele Detail

Summary

• Symbol: Mir155^tm1Rsky
• Name: microRNA 155; targeted mutation 1, Klaus Rajewsky
• MGI ID: MGI:3709846
• Synonyms: bic/miR-155^-, miR-155LacZ
• Gene: Mir155 Location: Chr16:84511028-84511092 bp, + strand Genetic Position: Chr16, 46.92 cM
• Alliance: Mir155^tm1Rsky page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121084
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 0.97 kb of bic exon 2 was replaced by an in-frame linear reporter cassette in which the lacZ reporter gene was in tandem with the NeoR gene flanked by loxP sites, allowing bic promoter to control lacZ gene expression. (J:121084)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir155 Mutation: 11 strains or lines available

References

• Original: J:121084 Thai TH, et al., Regulation of the germinal center response by microRNA-155. Science. 2007 Apr 27;316(5824):604-8
• All: 31 reference(s)