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Tg(Pax8-rtTA2S*M2)1Koes
Transgene Detail
Nomenclature
Symbol: Tg(Pax8-rtTA2S*M2)1Koes
Name: transgene insertion 1, Robert Koesters
MGI ID: MGI:3709326
Synonyms: Pax8-rtTA
Transgene: Tg(Pax8-rtTA2S*M2)1Koes  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA)F2
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailshe Pax8-rtTA construct contains an optimized rtTA variant (rtTA2s-M2) cDNA and SV40 polyA sequence replaced at the endogenous ATG translational start site of a murine Pax8 sequence. The rtTA2S*M2 variant contains 5 amino acid changes in the TetR moiety (S12G, E19G, A56P, D148E, and H179R) and a synthetic optimized transactivating domain, resulting in reduced basal activity and enhanced doxycycline sensitivity compared to wild-type rtTA. (J:140925)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Phenotypic Similarity to Human Syndrome: adult onset polycystic kidney disease in mice hemizygous for Tg(Pax8-rtTA2S*M2)1Koes and Tg(tetO-MYC)36aBop (J:1409250)

References
Original:  J:140925 Traykova-Brauch M, et al., An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med. 2008 Sep;14(9):979-84
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory