Tg(Pax8-rtTA2S*M2)1Koes
Transgene Detail

Summary

• Symbol: Tg(Pax8-rtTA2S*M2)1Koes
• Name: transgene insertion 1, Robert Koesters
• MGI ID: MGI:3709326
• Synonyms: Pax8-rtTA
• Transgene: Tg(Pax8-rtTA2S*M2)1Koes Location: unknown Genetic Position: Chr8, Syntenic
• Alliance: Tg(Pax8-rtTA2S*M2)1Koes page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F2

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The Pax8-rtTA construct contains an optimized rtTA variant (rtTA2s-M2) cDNA and SV40 polyA sequence replaced at the endogenous ATG translational start site of a murine Pax8 sequence. The rtTA2S*M2 variant contains 5 amino acid changes in the TetR moiety (S12G, E19G, A56P, D148E, and H179R) and a synthetic optimized transactivating domain, resulting in reduced basal activity and enhanced doxycycline sensitivity compared to wild-type rtTA. (J:140925)

Disease models

Expression

In Mice Carrying this Mutation:

27 assay results

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pax8-rtTA2S*M2)1Koes

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:140925 Traykova-Brauch M, et al., An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med. 2008 Sep;14(9):979-84
• All: 127 reference(s)