Rnf212^repro57
Chemically induced Allele Detail

Summary

• Symbol: Rnf212^repro57
• Name: ring finger protein 212; reproductive mutant 10, JAX Reproductive Mutagenesis Program
• MGI ID: MGI:3708256
• Gene: Rnf212 Location: Chr5:108877156-108922848 bp, - strand Genetic Position: Chr5, 53.24 cM
• Alliance: Rnf212^repro57 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU induced a C-to-T transversion at nucleotide 265 (at 108757107 bp in Chr5, GRCm38.p2) creating a premature stop codon in the coiled-coil domain of the gene. Western blot analysis confirmed the absence of protein expression in testes from homozygous mice. (J:219664)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rnf212 Mutation: 11 strains or lines available

Notes

Males are infertile: very low testis weight, low seminal vesicle weight, no epididymal sperm are recovered. Histological analysis shows arrest of spermatogenesis during late pachytene stage of meiotic prophase, some germ cells appear apoptotic.

References

• Original: J:92463 JAX Reproductive Mutagenesis Program, Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program. MGI Direct Data Submission. 2004-7
• All: 3 reference(s)