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Tg(tetO-APPSwInd)102Dbo
Transgene Detail
Nomenclature
Symbol: Tg(tetO-APPSwInd)102Dbo
Name: transgene insertion 102, David R Borchelt
MGI ID: MGI:3708167
Synonyms: tet-APPswe/ind (line 102), tet-APPswe/ind line 102
Transgene: Tg(tetO-APPSwInd)102Dbo  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x C3H/HeJ)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe mouse amyloid beta (A4) precursor protein (APP) sequence was modified to contain a humanized amyloid-beta (Abeta) domain. This mouse/human chimeric APP (mo/huAPP695 or APP695) was mutated to incorporate the Swedish (KM570/571NL) and Indiana (V617F) APP mutations associated with Alzheimer's disease. This APP695swe/ind sequence was placed downstream of the tetracycline-responsive (TRE or tetO) promoter and mouse prion protein exons 1-2. Line 102 was established. When mice are crossed with a line expressing a tTA transgene, these mice show the greatest doxycycline sensitivity for transgene suppression. (J:80782, J:109829)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:109829 Jankowsky JL, et al., Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med. 2005 Dec;2(12):e355
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory