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Targeted Allele Detail
Symbol: Sphk1tm1.1Cgh
Name: sphingosine kinase 1; targeted mutation 1, Shaun R Coughlin
MGI ID: MGI:3707992
Synonyms: SphK1-
Gene: Sphk1  Location: Chr11:116530925-116536674 bp, + strand  Genetic Position: Chr11, 81.42 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:120783
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA floxed neo cassette was inserted after exon 2 and a single loxP site was inserted after exon 6. In vivo Cre-mediated recombination then removed the neo cassette and exons 3 through 6 creating a null allele. (J:120783)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sphk1 Mutation:  4 strains or lines available
Original:  J:120783 Pappu R, et al., Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science. 2007 Apr 13;316(5822):295-8
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory