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Chd7Gt(S20-7E1)Sor
Gene trapped Allele Detail
Nomenclature
Symbol: Chd7Gt(S20-7E1)Sor
Name: chromodomain helicase DNA binding protein 7; gene trap S20-7E1, Philippe Soriano
MGI ID: MGI:3707678
Synonyms: Chd7Gt, Chd7Gt1Dmm, Chd7Gt(FHCRC-GT-S20-7E1)Sor, Chd7Gt(ROSAFARY)1Dmm
Gene: Chd7  Location: Chr4:8690406-8867659 bp, + strand  Genetic Position: Chr4, 3.68 cM
Abnormal development in Chd7Gt(S20-7E1)Sor/Chd7Gt(S20-7E1)Sor mice and delayed turning in Chd7Gt(S20-7E1)Sor/Chd7+ embryos

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  S20-7E1
Germline Transmission:  Earliest citation of germline transmission: J:119812
Parent Cell Line:  AK7.1 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Gene trapped
Mutation:    Insertion of gene trap vector     Vector: ROSAFARY
 
Mutation detailsThe gene trap vector ROSAFARY was inserted between exon 1 and 2 creating an exon 1/lacZ fusion transcript and an hyg fusion transcript with the remainder of the coding region. The absence of the normal splice product and the production of the two mutant variants was confirmed by RT-PCR. (J:119812)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 86 assay results
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chd7 Mutation:  36 strains or lines available
References
Original:  J:119812 Hurd EA, et al., Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues. Mamm Genome. 2007 Feb;18(2):94-104
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/16/2018
MGI 6.12
The Jackson Laboratory