Tg(ACTB-MAP2K1*K97M)1Stl
Transgene Detail

Summary

• Symbol: Tg(ACTB-MAP2K1*K97M)1Stl
• Name: transgene insertion 1, Susumu Tonegawa
• MGI ID: MGI:3707556
• Synonyms: dnMEK1, MEK^DN
• Transgene: Tg(ACTB-MAP2K1*K97M)1Stl Location: unknown
• Alliance: Tg(ACTB-MAP2K1*K97M)1Stl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTB-MAP2K1*K97M)1Stl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAP2K1 (5604)

  Map2k1

  (MGI:1346866)

• Mutation details: The transgene encodes a dominant-negative mutant (K97M) form of human MEK1 (or MAP2K1). Expression under the control of the chicken Actin beta promoter occurs only following Cre-mediated removal of the upstream Lox-STOP-Lox cassette. In the absence of Cre recombinase, the transgene is not detectably expressed in the brains of these floxed mice. If bred to a Cre-expressing strain, the floxed stop region is excised in the resulting offspring, and mutant MEK1 expression is observed in the cre-expressing tissue(s). (J:88546)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:88546 Kelleher RJ 3rd, et al., Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell. 2004 Feb 6;116(3):467-79
• All: 4 reference(s)