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Ikbketm1Tman
Targeted Allele Detail
Nomenclature
Symbol: Ikbketm1Tman
Name: inhibitor of kappaB kinase epsilon; targeted mutation 1, Tom Maniatis
MGI ID: MGI:3707541
Synonyms: Ikbke-
Gene: Ikbke  Location: Chr1:131254600-131279601 bp, - strand  Genetic Position: Chr1, 56.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119791
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129 and C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4-6 of the targeted gene were replaced with a PGK-neo cassette. Mice show a complete loss of the endogenous kinase function in lung, spleen, and embryonic fibroblasts. (J:119791)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ikbke Mutation:  3 strains or lines available
References
Original:  J:119791 Tenoever BR, et al., Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity. Science. 2007 Mar 2;315(5816):1274-8
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory