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Pdcd4tm1Yhcn
Targeted Allele Detail
Nomenclature
Symbol: Pdcd4tm1Yhcn
Name: programmed cell death 4; targeted mutation 1, Youhai H Chen
MGI ID: MGI:3707444
Synonyms: Pdcd4-
Gene: Pdcd4  Location: Chr19:53892231-53929860 bp, + strand  Genetic Position: Chr19, 48.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120583
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exons 3 and 4 with a neomycin resistance cassette. Absence of protein was confirmed in mutant lymphoid organs. (J:120583)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdcd4 Mutation:  12 strains or lines available
References
Original:  J:120583 Hilliard A, et al., Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4. J Immunol. 2006 Dec 1;177(11):8095-102
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory