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Targeted Allele Detail
Symbol: Crmp1tm1.1Swl
Name: collapsin response mediator protein 1; targeted mutation 1.1, Shu-Wha Lin
MGI ID: MGI:3707322
Synonyms: Crmp1-
Gene: Crmp1  Location: Chr5:37242058-37292163 bp, + strand  Genetic Position: Chr5, 19.96 cM
Germline Transmission:  Earliest citation of germline transmission: J:120105
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA multi-step targeting process consisting of the insertion and subsequent removal of a floxed HPRT cassette into intron 5, and the insertion of a second floxed HPRT cassette into intron 3 resulted in the flanking of exons 4-5 with loxP sites. Transient cre expression ultimately excised both exons and the second HPRT cassette. Northern blot and Western blot confirmed absence of transcript and protein, respectively, in mutants. (J:120105)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crmp1 Mutation:  28 strains or lines available
Original:  J:120105 Su KY, et al., Mice deficient in collapsin response mediator protein-1 exhibit impaired long-term potentiation and impaired spatial learning and memory. J Neurosci. 2007 Mar 7;27(10):2513-24
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory