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Cebpatm5Nerl
Targeted Allele Detail
Nomenclature
Symbol: Cebpatm5Nerl
Name: CCAAT/enhancer binding protein (C/EBP), alpha; targeted mutation 5, Claus Nerlov
MGI ID: MGI:3707189
Synonyms: CebpadeltaPHR, DeltaPHR
Gene: Cebpa  Location: Chr7:35119293-35121926 bp, + strand  Genetic Position: Chr7, 21.02 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120098
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsAn in-frame deletion of amino acids 180-194 resulted in the loss of S193 and the associated PHR Cdk2/4 interaction motif. Western blot confirmed that mutants produced proteins slightly smaller than, but equal in abundance to, the wild-type allele. (J:120098)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cebpa Mutation:  3 strains or lines available
References
Original:  J:120098 Pedersen TA, et al., Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. EMBO J. 2007 Feb 21;26(4):1081-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory