Runx1^tm8Spe
Targeted Allele Detail

Summary

• Symbol: Runx1^tm8Spe
• Name: runt related transcription factor 1; targeted mutation 8, Nancy A Speck
• MGI ID: MGI:3707173
• Synonyms: T161A
• Gene: Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
• Alliance: Runx1^tm8Spe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:120100
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert the T161A mutation into exon 4 with a floxed neo in intron 4. (J:120100)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx1 Mutation: 35 strains or lines available

Notes

ES cell line = J1 (129S4/SvJae) or R1 (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

References

• Original: J:120100 Matheny CJ, et al., Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles. EMBO J. 2007 Feb 21;26(4):1163-75
• All: 1 reference(s)