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Mapk14tm1.1Dvb
Targeted Allele Detail
Nomenclature
Symbol: Mapk14tm1.1Dvb
Name: mitogen-activated protein kinase 14; targeted mutation 1.1, Dmitry V Bulavin
MGI ID: MGI:3706998
Synonyms: p38AF, p38alphaki
Gene: Mapk14  Location: Chr17:28691342-28748404 bp, + strand  Genetic Position: Chr17, 14.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120284
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsRegulatory sites Thr180 and Tyr182 are replaced by alanine and phenylalanine, respectively. A floxed neo cassette inserted downstream of exon 8 was removed by germ line, cre mediated recombination. (J:120284, J:151980)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk14 Mutation:  17 strains or lines available
References
Original:  J:120284 Shreeram S, et al., Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med. 2006 Dec 25;203(13):2793-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory