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Targeted Allele Detail
Symbol: Scmh1tm1Hko
Name: sex comb on midleg homolog 1; targeted mutation 1, Haruhiko Koseki
MGI ID: MGI:3706668
Gene: Scmh1  Location: Chr4:120405281-120530186 bp, + strand  Genetic Position: Chr4, 56.52 cM, cytoband D1-D2
Germline Transmission:  Earliest citation of germline transmission: J:119909
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exonic regions containing the SPM domain are replaced with a neo cassette. The absence of the 3.5Kb transcript was confirmed by northern blot analysis of homozygous testes; however, a small amount of truncated transcript is present. (J:119909)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scmh1 Mutation:  76 strains or lines available
Original:  J:119909 Takada Y, et al., Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. Development. 2007 Feb;134(3):579-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.10
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