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Transgene Detail
Symbol: Tg(Ins2-Nos2)40Okam
Name: transgene insertion 40, Hiroshi Okamoto
MGI ID: MGI:3706439
Synonyms: line 40
Transgene: Tg(Ins2-Nos2)40Okam  Location: unknown  
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Ins2-Nos2)40Okam expresses 1 gene
Mutation detailsThe transgenic construct was composed of the rat insulin II promoter and the 3.5 kb cDNA fragment containing the entire mouse Nos2 gene coding region with the SV40 intron/polyadenylation signal ligated to it. Line 31 was subsequently established. Western blot analysis shows expression of Nos2 in pancreatic islets, but nowhere else. (J:45520)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
J:116040 uses transgenic Nos2 mice with no identification of the line. The two lines created in J:45520 are similar, with line 40 having a more severe phenotype. Assumption was made that line 40 was used subsequently for this reason. rpb 05/01/2007
Original:  J:45520 Takamura T, et al., Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis. J Biol Chem. 1998 Jan 30;273(5):2493-6
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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