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Tg(Ins2-Nos2)31Okam
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-Nos2)31Okam
Name: transgene insertion 31, Hiroshi Okamoto
MGI ID: MGI:3706438
Synonyms: line 31
Transgene: Tg(Ins2-Nos2)31Okam  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ins2-Nos2)31Okam expresses 1 gene
 
Mutation detailsThe transgenic construct was composed of the rat insulin II promoter and the 3.5 kb cDNA fragment containing the entire mouse Nos2 gene coding region with the SV40 intron/polyadenylation signal ligated to it. Line 31 was subsequently established. Western blot analysis shows expression of Nos2 in pancreatic islets, but nowhere else. (J:45520)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:45520 Takamura T, et al., Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis. J Biol Chem. 1998 Jan 30;273(5):2493-6
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory