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Tg(tetO-BMPR2*T504)1Jwst
Transgene Detail
Nomenclature
Symbol: Tg(tetO-BMPR2*T504)1Jwst
Name: transgene insertion 1, James West
MGI ID: MGI:3703793
Synonyms: tetO7-BMPRIIdelx+, TetO7-BMPRIIdelx4+
Transgene: Tg(tetO-BMPR2*T504)1Jwst  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO-BMPR2*T504)1Jwst expresses 1 gene
 
Mutation detailsSeven copies of the tetracycline responsive element and the CMV minimal promotor were used to drive expression of a dominant-negative mutant BMPR2. The BMPR2 mutation is insertion of a T at base 504 in the kinase (4th) domain of the protein, resulting in a premature stop 18 amino acids into the kinase domain. These transgenic mice were crossed to Tg(Tagln-rtTA)E1Jwst mice to obtain mice with inducible, muscle-specific expression of dominant negative BMPR2. (J:98898)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:98898 West J, et al., Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res. 2004 Apr 30;94(8):1109-14
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory