About   Help   FAQ
Targeted Allele Detail
Symbol: Man1a2tm1.1Ahe
Name: mannosidase, alpha, class 1A, member 2; targeted mutation 1.1, Annette Herscovics
MGI ID: MGI:3703789
Synonyms: Man1B-
Gene: Man1a2  Location: Chr3:100469519-100592789 bp, - strand  Genetic Position: Chr3, 43.71 cM
Thick interalveolar septae and alveolar hemorrhaging in E18.5 Man1a2tm1.1Ahe/Man1a2tm1.1Ahe lungs

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:119977
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe floxed exon 2 in Man1a2tm1Ahe was removed via transient transfection with Cre recombinase. Excision of the floxed exon causes a frameshift and introduces a stop codon immediately following exon 1. RT-PCR confirmed the loss of gene expression in various tissues. (J:119977)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 17 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Man1a2 Mutation:  24 strains or lines available
Original:  J:119977 Tremblay LO, et al., Respiratory distress and neonatal lethality in mice lacking Golgi alpha1,2-mannosidase IB involved in N-glycan maturation. J Biol Chem. 2007 Jan 26;282(4):2558-66
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.17
The Jackson Laboratory