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Crymtm1Sasu
Targeted Allele Detail
Nomenclature
Symbol: Crymtm1Sasu
Name: crystallin, mu; targeted mutation 1, Satoru Suzuki
MGI ID: MGI:3703787
Gene: Crym  Location: Chr7:119785603-119801212 bp, - strand  Genetic Position: Chr7, 64.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119707
Parent Cell Line:  IT2 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 and 2 were replaced with a neo cassette. A Northern blot hybridization and Western blotting confirmed the absence of the RNA and protein in homozygotes. (J:119707)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Crym Mutation:  25 strains or lines available
References
Original:  J:119707 Suzuki S, et al., micro-Crystallin as an intracellular 3,5,3'-triiodothyronine holder in vivo. Mol Endocrinol. 2007 Apr;21(4):885-94
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory