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Tg(H2-K-AKR1B1)1Tj
Transgene Detail
Nomenclature
Symbol: Tg(H2-K-AKR1B1)1Tj
Name: transgene insertion 1, University of Tokushima School of Medicine
MGI ID: MGI:3703741
Synonyms: hAR-Tg
Transgene: Tg(H2-K-AKR1B1)1Tj  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(H2-K-AKR1B1)1Tj expresses 1 gene
 
Mutation detailsExpression of the full length human aldose reductase (AKR1B1) cDNA is under control of the murine H2-Kd promoter. Northern and Wester blotting shows expression of human aldose reductase mRNA and protein in all tissues tested. (J:120049)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:120049 Yamaoka T, et al., Acute onset of diabetic pathological changes in transgenic mice with human aldose reductase cDNA. Diabetologia. 1995 Mar;38(3):255-61
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory