About   Help   FAQ
Smad2tm1.1Epb
Targeted Allele Detail
Nomenclature
Symbol: Smad2tm1.1Epb
Name: SMAD family member 2; targeted mutation 1.1, Erwin P Bottinger
MGI ID: MGI:3703160
Synonyms: Smad2f
Gene: Smad2  Location: Chr18:76374651-76444034 bp, + strand  Genetic Position: Chr18, 51.42 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119642
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 2, which contains the ATG, remained flanked by loxP sites following in vivo cre-mediated recombination by crossing floxed mice with cre mice. A floxed pgk-neomycin resistance cassette was removed from the locus. (J:119642)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smad2 Mutation:  39 strains or lines available
References
Original:  J:119642 Ju W, et al., Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol Cell Biol. 2006 Jan;26(2):654-67
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/23/2021
MGI 6.17
The Jackson Laboratory