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Portm2Ding
Targeted Allele Detail
Nomenclature
Symbol: Portm2Ding
Name: cytochrome p450 oxidoreductase; targeted mutation 2, Xinxin Ding
MGI ID: MGI:3703087
Synonyms: Cprlow
Gene: Por  Location: Chr5:135698894-135764180 bp, + strand  Genetic Position: Chr5, 75.34 cM, cytoband G1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119630
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsThe insertion of a floxed neomycin resistance cassette into intron 15 resulted in hypomorphic expression of this allele. An additional loxP site was inserted into intron 2. (J:119630)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Por Mutation:  67 strains or lines available
References
Original:  J:119630 Wu L, et al., Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450. J Pharmacol Exp Ther. 2005 Jan;312(1):35-43
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory