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Targeted Allele Detail
Symbol: Wwtr1tm1Whun
Name: WW domain containing transcription regulator 1; targeted mutation 1, Walter Hunziker
MGI ID: MGI:3702742
Synonyms: Wwtr1-
Gene: Wwtr1  Location: Chr3:57363070-57483331 bp, - strand  Genetic Position: Chr3, 27.74 cM
Gross anatomy of skeleton and renal histology of Wwtr1tm1Whun/Wwtr1tm1Whun mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:119488
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert a lacZ-neo cassette in frame into the second exon immediately downstream of the initiation ATG. Western blot failed to detect protein in mutant kidney samples, and lacZ expression was detected by X-gal staining. (J:119488)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wwtr1 Mutation:  17 strains or lines available
Original:  J:119488 Hossain Z, et al., Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1631-6
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory