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Targeted Allele Detail
Symbol: Tcrbtm4Slek
Name: T cell receptor beta chain; targeted mutation 4, Barry P Sleckman
MGI ID: MGI:3702580
Synonyms: Jbeta1M5
Gene: Tcrb  Location: Chr6:40891296-41558371 bp, + strand  Genetic Position: Chr6, cytoband A-C
Germline Transmission:  Earliest citation of germline transmission: J:119552
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsES cells containing Tcrbtm1Slek, which contain a loxP site in place of the Dbeta2-Jbeta2 gene cluster, were targeted with a vector to remove remove Dbeta1 and its flanking RSSs from the locus. The vector also replaced the Jb1.2 12 RSS with the 5' Dbeta1 12-RSS. (J:119552)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcrb Mutation:  83 strains or lines available
Original:  J:119552 Bassing CH, et al., Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature. 2000 Jun 1;405(6786):583-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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