Gt(ROSA)26Sortm1(cre/ERT2)Thl
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(cre/ERT2)Thl |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Thomas Ludwig |
MGI ID: |
MGI:3701992 |
Synonyms: |
ERCre, Gt(ROSA)26Sor-CreER, Gt(ROSA)26Sortm1(cre/ESR1)Thl, ROSA26Cre-ERT2 |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(cre/ERT2)Thl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:104582
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(cre/ERT2)Thl expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Gt(ROSA)26Sor (MGI:104735) |
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Mutation details: DNA sequence encoding a fusion protein comprised of cre recombinase and a mutated ligand binding domain of Esr1 (ERT2) was inserted at the endogenous locus via homologous recombination. Activation of cre recombinase activity is dependent on the administration of 4-OH-tamoxifen.
(J:104582)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Gt(ROSA)26Sor
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
942 strains or lines available
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Original: |
J:104582 de Luca C, et al., Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. J Clin Invest. 2005 Dec;115(12):3484-93 |
All: |
117 reference(s) |
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