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Targeted Allele Detail
Symbol: Kmt2atm1.1(Sh3gl1)Lcc
Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1.1, Li Chong Chan
MGI ID: MGI:3701943
Synonyms: MllEenINV
Gene: Kmt2a  Location: Chr9:44803355-44881296 bp, - strand  Genetic Position: Chr9, 24.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:205605
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change)
Mutations:    Insertion, Intragenic deletion
Kmt2atm1.1(Sh3gl1)Lcc expresses 1 gene
Mutation detailsA cassette containing a splice acceptor, the open reading frame of Sh3gl1, an IRES-EGFP and an FRT-flanked neomycin resistance cassette was flanked by inward facing loxP sites and inserted in opposite orientation between exon 8 and 9. Flp-mediated recombination removed the selection cassette. Cre-mediated inversion is required to achieve expression of the fusion at exon 8. The fusion products mimick a fusion found in human patients with leukemia. (J:205605)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kmt2a Mutation:  79 strains or lines available
ES cell line = L4.
Original:  J:205605 Ng RK, et al., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model. J Pathol. 2014 Jan;232(1):65-74
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory