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Kmt2atm1.1(Sh3gl1)Lcc
Targeted Allele Detail
Nomenclature
Symbol: Kmt2atm1.1(Sh3gl1)Lcc
Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1.1, Li Chong Chan
MGI ID: MGI:3701943
Synonyms: MllEenINV
Gene: Kmt2a  Location: Chr9:44803355-44881296 bp, - strand  Genetic Position: Chr9, 24.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205605
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, No functional change)
Mutations:    Insertion, Intragenic deletion
 
Kmt2atm1.1(Sh3gl1)Lcc expresses 1 gene
 
Mutation detailsA cassette containing a splice acceptor, the open reading frame of Sh3gl1, an IRES-EGFP and an FRT-flanked neomycin resistance cassette was flanked by inward facing loxP sites and inserted in opposite orientation between exon 8 and 9. Flp-mediated recombination removed the selection cassette. Cre-mediated inversion is required to achieve expression of the fusion at exon 8. The fusion products mimick a fusion found in human patients with leukemia. (J:205605)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kmt2a Mutation:  79 strains or lines available
Notes
ES cell line = L4.
References
Original:  J:205605 Ng RK, et al., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model. J Pathol. 2014 Jan;232(1):65-74
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory