Tg(Emx1-cre)2Ito
Transgene Detail

Summary

• Symbol: Tg(Emx1-cre)2Ito
• Name: transgene insertion 2, Shigeyoshi Itohara
• MGI ID: MGI:3701618
• Synonyms: Tg2
• Transgene: Tg(Emx1-cre)2Ito Location: unknown
• Alliance: Tg(Emx1-cre)2Ito page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Emx1-cre)2Ito expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Emx1 (MGI:95387)

• Mutation details: An Emx1 positive PAC clone frome the RPCI-21 PAC mouse genomic library (PAC-Emx1#1) was modified by the insertion of an NLS-Cre-poly(A) cassette into the NotI site by homologous recombination in bacteria. Two independent recombination events were identified. This transgenic line was generated from the PAC-Cre-A fragment and has 2-3 copies of the transgene. (J:88421)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Emx1 (mouse) Summary of all recombinase alleles driven by Emx1. Comparative matrix view of recombinase activities Alliance mouse Emx1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Adult expression of this transgene is seen in the olfactory bulb, neocortex, piriform cortex, hippocampus and amygdala of the brain. At 7-8 days of age expression expression is weak in the olfactory bulb, ventral parts of the cerebral cortex, and the amygdala. No activity is seen in the thalamus. Activity is primarily in excitatory neurons and astrocytes. Little or no activity is seen in inhibitory neurons.

References

• Original: J:88421 Iwasato T, et al., Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis. 2004 Mar;38(3):130-8
• All: 1 reference(s)