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Hamptm1Svl
Targeted Allele Detail
Nomenclature
Symbol: Hamptm1Svl
Name: hepcidin antimicrobial peptide; targeted mutation 1, Sophie Vaulont
MGI ID: MGI:3701082
Synonyms: Hamp1-, Hepc1-
Gene: Hamp  Location: Chr7:30942371-30944017 bp, - strand  Genetic Position: Chr7, 19.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119004
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    The first two exons and part of exon 3 was replaced with a PGK-hygromycin cassette. (J:119004)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hamp Mutation:  3 strains or lines available
References
Original:  J:119004 Lesbordes-Brion JC, et al., Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood. 2006 Aug 15;108(4):1402-5
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory