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Ptpn9tm1Dny
Targeted Allele Detail
Nomenclature
Symbol: Ptpn9tm1Dny
Name: protein tyrosine phosphatase, non-receptor type 9; targeted mutation 1, Gregory P Downey
MGI ID: MGI:3700988
Synonyms: Meg2-
Gene: Ptpn9  Location: Chr9:56994968-57062805 bp, + strand  Genetic Position: Chr9, 30.7 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118880
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 10-12 and part of exon 13 were replaced with a neomycin resistance gene. Northern and Western blot confirmed absence of transcript and protein, respectively. (J:118880)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn9 Mutation:  10 strains or lines available
References
Original:  J:118880 Wang Y, et al., Tyrosine phosphatase MEG2 modulates murine development and platelet and lymphocyte activation through secretory vesicle function. J Exp Med. 2005 Dec 5;202(11):1587-97
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory