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Acacatm1.1Jkus
Targeted Allele Detail
Nomenclature
Symbol: Acacatm1.1Jkus
Name: acetyl-Coenzyme A carboxylase alpha; targeted mutation 1.1, Jun Kusunoki
MGI ID: MGI:3700955
Synonyms: Acc1-, Acc1deltaex46
Gene: Acaca  Location: Chr11:84129672-84401651 bp, + strand  Genetic Position: Chr11, 51.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118861
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 46 was removed via cre-mediated recombination in the germline. Neither wild-type nor truncated protein was expressed from the locus. (J:118861)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 30 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acaca Mutation:  13 strains or lines available
References
Original:  J:118861 Harada N, et al., Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. Mol Cell Biol. 2007 Mar;27(5):1881-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory