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Tg(Tcra2D2,Tcrb2D2)1Kuch
Transgene Detail
Nomenclature
Symbol: Tg(Tcra2D2,Tcrb2D2)1Kuch
Name: transgene insertion 1, Vijay Kuchroo
MGI ID: MGI:3700794
Synonyms: 2D2, 2D2 TCR, MOGTCR, MOG TCR, TCRMOG, TCRMOG
Transgene: Tg(Tcra2D2,Tcrb2D2)1Kuch  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tcra2D2,Tcrb2D2)1Kuch expresses 2 genes
 
Mutation detailsThe Valpha3.2Jalpha18 region of Tcra from the 2D2 T cell clone as well as the Vbeta11DJbeta1,1 region of Tcrb from the same 2D2 clone were inserted into TCR expression cassettes. The linearized plasmids were injected into the pronuclei of fertilized C57BL/6 oocytes. The 2D2 clone was purified from C57BL/6 mice immunized with a peptide from myelin oligodendrocyte glycoprotein (MOG). The amino acid sequence of the CDR3 region from TCR alpha is VYF CALRSY NFG and that from TCR beta is CASS LDCG ANP. (J:83278)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:83278 Bettelli E, et al., Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003 May 5;197(9):1073-81
All:  125 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory