About   Help   FAQ
Syne1tm1Rexu
Targeted Allele Detail
Nomenclature
Symbol: Syne1tm1Rexu
Name: spectrin repeat containing, nuclear envelope 1; targeted mutation 1, Rener Xu
MGI ID: MGI:3700735
Synonyms: Syne-1-
Gene: Syne1  Location: Chr10:5020203-5550692 bp, - strand  Genetic Position: Chr10, 2.01 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118671
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe last exon was replaced with a neo cassette. RT-PCR confirmed removal of the KASH domain. Immunohistochemistry confirmed loss of localization of the protein to the nuclear envelope in homozygous skeletal muscle cells. (J:118671)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Syne1 Mutation:  19 strains or lines available
References
Original:  J:118671 Zhang X, et al., Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. Development. 2007 Mar;134(5):901-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory