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Targeted Allele Detail
Symbol: Eif4ebp1tm1Pjb
Name: eukaryotic translation initiation factor 4E binding protein 1; targeted mutation 1, Paul J Blackshear
MGI ID: MGI:3700567
Synonyms: PHAS-I-
Gene: Eif4ebp1  Location: Chr8:27260327-27275656 bp, + strand  Genetic Position: Chr8, 15.95 cM, cytoband A4-B1
Germline Transmission:  Earliest citation of germline transmission: J:44600
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a ne cassette via homologous recombination. Northern blot analysis detected expression of a novel transcript and and western blot analysis confirmed the absence of protein in homozygous MEFs. (J:44600)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eif4ebp1 Mutation:  17 strains or lines available
Original:  J:44600 Blackshear PJ, et al., Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice. J Biol Chem. 1997 Dec 12;272(50):31510-4
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory