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Dlg4tm1Rlh
Targeted Allele Detail
Nomenclature
Symbol: Dlg4tm1Rlh
Name: discs large MAGUK scaffold protein 4; targeted mutation 1, Richard L Huganir
MGI ID: MGI:3700207
Synonyms: Dlg4-
Gene: Dlg4  Location: Chr11:70017203-70045535 bp, + strand  Genetic Position: Chr11, 42.96 cM, cytoband B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118286
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons encoding PDZ 1 and 2 domains were replaced with a neomycin resistance cassette. This results in the production of an out of frame transcript. Western blot confirmed absence of protein in mutant mice. (J:118286)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dlg4 Mutation:  25 strains or lines available
References
Original:  J:118286 Beique JC, et al., Synapse-specific regulation of AMPA receptor function by PSD-95. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19535-40
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory