Tg(Cdh5-cre/ERT2)CIVE23Mlia
Transgene Detail

Summary

• Symbol: Tg(Cdh5-cre/ERT2)CIVE23Mlia
• Name: transgene insertion CIVE23, M Luisa Iruela-Arispe
• MGI ID: MGI:3700149
• Synonyms: 236849, Tg(Cdh5-cre)CIVE23Mlia, VECad-Cre-ER^T2, VE-Cadherin-CreERT2, VE-Cadherin^iCre
• Transgene: Tg(Cdh5-cre/ERT2)CIVE23Mlia Location: unknown Genetic Position: Chr3, Syntenic
• Alliance: Tg(Cdh5-cre/ERT2)CIVE23Mlia page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Duplication, Insertion
• Tg(Cdh5-cre/ERT2)CIVE23Mlia expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cdh5 (MGI:105057)

• Mutation details: The Cre-ERT2 expression cassette was placed under the regulatory control of the mouse cadherin 5 promoter. 8 lines were obtained. Line CIVE23 inserted 138 kb upstream of Ankrd50 (chr3:38,522,028; NCBI37/mm9) with a fragment of Vat1l and a 87.6 kb genomic duplication occured at the integration site. (J:116638, J:240920)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh5 (mouse) Summary of all recombinase alleles driven by Cdh5. Comparative matrix view of recombinase activities Alliance mouse Cdh5 gene page

Tumor Data

List all tumor models in MMHCdb carrying Tg(Cdh5-cre/ERT2)CIVE23Mlia

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:116638 Monvoisin A, et al., VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Dev Dyn. 2006 Dec;235(12):3413-22
• All: 67 reference(s)