About   Help   FAQ
Pstc6CAST/EiJ
QTL Variant Detail
Summary
QTL variant: Pstc6CAST/EiJ
Name: periosteal circumference 6; CAST/EiJ
MGI ID: MGI:3699726
QTL: Pstc6  Location: unknown  Genetic Position: Chr9, cM position of peak correlated region/allele: 35.39 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  CAST/EiJ
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:118314

Linkage analysis was performed on 328 (MRL/MpJ x CAST/EiJ)F2 animals to identify novel genetic loci associated with bone size and density traits. Parental strain CAST/EiJ displays decreased body size, femur length, femur periosteal and endosteal circumference, and mid-diaphyseal femur bone mineral density (BMD) compared to parental strain MRL/MpJ. A panel of 86 polymorphic markers at an average spacing of 17 cM was used for the genome scan.

A novel QTL for femur BMD mapped to 24 cM on mouse Chromosome 10 near D10Mit31 (LOD=3.4). This locus explains 8.9% of the variance and is designated Bmd38 (bone mineral density 38). CAST/EiJ-derived alleles at Bmd38 confer increased bone density. Bmd38 interacts with loci on mouse Chromosomes 5 (45 cM), 8 (15 cM), 14 (10 cM), and 19 (0 cM).

Suggestive linkage to femur BMD mapped to 22.7 cM on mouse Chromosome 15 near D15Mit115. MRL/MpJ-derived alleles at D15Mit115 confer increased bone density. This locus displays significant interaction with mouse Chromosome 19 at25 cM (LOD=4). Pcir3 (33.4 cM) is a previously identified QTL mapping near this region.

Significant linkage to femur periosteal circumference mapped to 31 cM on mouse Chromosome 9 near D9Mit336 (LOD=3.5). This locus explains 7.5% of the variance and is designated Pstc6 (periosteal circumference 6). MRL/MpJ-derived alleles at Pstc6 confer increased femur periosteal circumference. Pstc6 also exhibits significant linkage to femur endosteal circumference (LOD=5.1), forearm total BMD (LOD=4), forearm periosteal circumference (LOD=4.2), and forearm endosteal circumference (LOD=4.2). Pstc6 interacts with loci on chromosomes 2 (75 cM), 3 (20 cM), and Bmd38 on chromosome 10.

Suggestive linkage to femur periosteal circumference mapped to mouse Chromosome 2 near D2Mit411 (LOD=3). MRL/MpJ-derived alleles at D2Mit411 confer increased periosteal circumference. This locus explains 11% of the variance.

References
Original:  J:118314 Yu H, et al., Detecting Novel Bone Density and Bone Size Quantitative Trait Loci Using a Cross of MRL/MpJ and CAST/EiJ Inbred Mice. Calcif Tissue Int. 2007 Feb;80(2):103-10
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory