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Kcne2tm1Gwab
Targeted Allele Detail
Nomenclature
Symbol: Kcne2tm1Gwab
Name: potassium voltage-gated channel, Isk-related subfamily, gene 2; targeted mutation 1, Geoffrey W Abbott
MGI ID: MGI:3699589
Synonyms: Kcne2-
Gene: Kcne2  Location: Chr16:92292389-92298129 bp, + strand  Genetic Position: Chr16, 53.55 cM
Kcne2tm1Gwab/Kcne2tm1Gwab mice have enlarged stomachs

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116518
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neomycin resistance cassette. Western blot confirmed absence of protein in mutant stomach samples. (J:116518)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcne2 Mutation:  7 strains or lines available
References
Original:  J:116518 Roepke TK, et al., The KCNE2 potassium channel ancillary subunit is essential for gastric acid secretion. J Biol Chem. 2006 Aug 18;281(33):23740-7
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory