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Targeted Allele Detail
Symbol: Casktm1.1Sud
Name: calcium/calmodulin-dependent serine protein kinase (MAGUK family); targeted mutation 1.1, Thomas C Sudhof
MGI ID: MGI:3699428
Synonyms: CASK KO
Gene: Cask  Location: ChrX:13517080-13851367 bp, - strand  Genetic Position: ChrX, 8.43 cM
Cleft palate in Casktm1Sud/Casktm1.1Sud Tg(Prm-cre)580g/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:117978
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsCrossing Casktm1Sud mutants with cre-expressing mice results in excision of the floxed exon and neomycin cassette creating a null allele. Cask expression is decreased ~33% in heterozygotes and is abolished in homozygotes. (J:117978)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cask Mutation:  13 strains or lines available
Original:  J:117978 Atasoy D, et al., Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2525-30
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory