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Targeted Allele Detail
Symbol: Fgfr2tm1Schl
Name: fibroblast growth factor receptor 2; targeted mutation 1, Joseph Schlessinger
MGI ID: MGI:3699313
Synonyms: Fgfr2cC342Y
Gene: Fgfr2  Location: Chr7:130162451-130266808 bp, - strand  Genetic Position: Chr7, 73.19 cM
Crouzon-Like Syndrome characterization, skull scan and histological sections of Fgfr2tm1Schl/Fgfr2+ and Fgfr2tm2Schl/Fgfr2+ mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:118299
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to replace cysteine 342 with a tyrosine (C342Y) in exon 9. A floxed neo was inserted into intron 9 and subsequently removed by cre mediated recombination. (J:118299)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  22 strains or lines available
Original:  J:118299 Eswarakumar VP, et al., Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis. Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18603-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory