Bckdk^{Gt(VICT48)710Lex}
Gene trapped Allele Detail

Summary

• Symbol: Bckdk^{Gt(VICT48)710Lex}
• Name: branched chain ketoacid dehydrogenase kinase; gene trap 710, Lexicon Genetics
• MGI ID: MGI:3699162
• Synonyms: BDK^-
• Gene: Bckdk Location: Chr7:127503245-127508836 bp, + strand Genetic Position: Chr7, 69.82 cM
• Alliance: Bckdk^{Gt(VICT48)710Lex} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117564
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The VICTR48 gene trap vector was inserted into intron 1. Western blot failed to detect protein in mutants. (J:117564)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bckdk Mutation: 45 strains or lines available

References

• Original: J:117564 Joshi MA, et al., Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice. Biochem J. 2006 Nov 15;400(1):153-62
• All: 5 reference(s)