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Ptgs2tm2.1(Ptgs1)Fun
Targeted Allele Detail
Nomenclature
Symbol: Ptgs2tm2.1(Ptgs1)Fun
Name: prostaglandin-endoperoxide synthase 2; targeted mutation 2.1, Colin D Funk
MGI ID: MGI:3699107
Synonyms: COX-1 > COX-2
Gene: Ptgs2  Location: Chr1:150100031-150108227 bp, + strand  Genetic Position: Chr1, 63.84 cM, cytoband H1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118171
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed neo was removed from the locus, leaving cDNA encoding encoding prostaglandin-endoperoxide synthase 1 to replace most of the coding region of the endogenous locus (exons 1-9). (J:118171)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptgs2 Mutation:  43 strains or lines available
References
Original:  J:118171 Yu Y, et al., Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. J Biol Chem. 2007 Jan 12;282(2):1498-506
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory