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Foxo1tm1.1Rdp
Targeted Allele Detail
Nomenclature
Symbol: Foxo1tm1.1Rdp
Name: forkhead box O1; targeted mutation 1.1, Ronald DePinho
MGI ID: MGI:3698868
Synonyms: Foxo1-
Gene: Foxo1  Location: Chr3:52268337-52350109 bp, + strand  Genetic Position: Chr3, 23.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118179
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 2 was removed via cre-mediated recombination. Northern blot confirmed absence of transcript in mutants. (J:118179)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxo1 Mutation:  7 strains or lines available
Notes

Phenotypic Similarity to Human Syndrome: Granulosa Cell Tumor of the ovary J:232961.

References
Original:  J:118179 Paik JH, et al., FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell. 2007 Jan 26;128(2):309-23
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory