Mapkapk3^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Mapkapk3^tm1.1Lex
• Name: mitogen-activated protein kinase-activated protein kinase 3; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:3698628
• Synonyms: MK3-
• Gene: Mapkapk3 Location: Chr9:107132126-107167076 bp, - strand Genetic Position: Chr9, 57.98 cM
• Alliance: Mapkapk3^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117668
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 1 and 2 including the translation start site were removed by Cre mediated recombination. Western blot analysis of spleen lysates confirms absence of protein in homozygous mice. (J:117668)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapkapk3 Mutation: 22 strains or lines available

References

• Original: J:117668 Ronkina N, et al., The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol. 2007 Jan;27(1):170-81
• All: 10 reference(s)