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Ryr2tm1Nobs
Targeted Allele Detail
Nomenclature
Symbol: Ryr2tm1Nobs
Name: ryanodine receptor 2, cardiac; targeted mutation 1, Noboru Suzuki
MGI ID: MGI:3698416
Gene: Ryr2  Location: Chr13:11553103-12106945 bp, - strand  Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117828
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 2 with a cassette containing CAG-loxP-stop-loxP-KrasG12V-IRES-NL-lacZ-pA-neo. (J:117828)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ryr2 Mutation:  157 strains or lines available
References
Original:  J:117828 Tsumura H, et al., Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice. Oncogene. 2006 Dec 14;25(59):7673-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/11/2017
MGI 6.08
The Jackson Laboratory