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Ddb1tm1Spg
Targeted Allele Detail
Nomenclature
Symbol: Ddb1tm1Spg
Name: damage specific DNA binding protein 1; targeted mutation 1, Stephen P Goff
MGI ID: MGI:3698413
Synonyms: DDB1F
Gene: Ddb1  Location: Chr19:10605492-10629822 bp, + strand  Genetic Position: Chr19, 6.66 cM, cytoband centromere
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117820
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert loxP sites flanking exon 5. In vitro expression of cre recombinase resulted in the loss of a floxed neomycin resistance cassette. (J:117820)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddb1 Mutation:  9 strains or lines available
References
Original:  J:117820 Cang Y, et al., Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells. Cell. 2006 Dec 1;127(5):929-40
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory