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Ctsktm1Ypl
Targeted Allele Detail
Summary
Symbol: Ctsktm1Ypl
Name: cathepsin K; targeted mutation 1, Yi-Ping Li
MGI ID: MGI:3698312
Gene: Ctsk  Location: Chr3:95406567-95416673 bp, + strand  Genetic Position: Chr3, 40.74 cM
Alliance: Ctsktm1Ypl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117870
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exons 1 and 2 with a neomycin resistance cassette. Northern blot confirmed absence of transcript in mutants. (J:117870)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctsk Mutation:  29 strains or lines available
References
Original:  J:117870 Chen W, et al., Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence. Hum Mol Genet. 2007 Feb 15;16(4):410-23
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory