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Targeted Allele Detail
Symbol: Ybx1tm1Tuch
Name: Y box protein 1; targeted mutation 1, Takeshi Uchiumi
MGI ID: MGI:3698273
Synonyms: YB-1-
Gene: Ybx1  Location: Chr4:119277981-119294604 bp, - strand  Genetic Position: Chr4, 55.34 cM, cytoband D1
Exencephaly in Ybx1tm1Tuch/Ybx1tm1Tuch embryos

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:117977
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exons 5 and 6 were replaced with a neomycin resistance gene. (J:117977)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ybx1 Mutation:  12 strains or lines available
Original:  J:117977 Shibahara K, et al., Targeted disruption of one allele of the Y-box binding protein-1 (YB-1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C. Cancer Sci. 2004 Apr;95(4):348-53
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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