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QTL Variant Detail
QTL variant: Rfpw4C57BL/6J
Name: retroperitoneal fat pad weight 4; C57BL/6J
MGI ID: MGI:3698237
QTL: Rfpw4  Location: unknown  Genetic Position: Chr10, Syntenic
Strain of Specimen:  C57BL/6J
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for the genome scan. Parental strain C57BL/6J displays decreased activity and increased body weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.

Linkage to percent body fat, named Pbft2, mapped to 42 cM on mouse Chromosome 10 with LOD=5.83. Linkage to mesenteric and omental fat pad weight mapped to 40 cM (Mofp3, LOD=6.13) in both sexes and to 28 cM (Mofp6, LOD=3.71) in females only. Linkage to gonadal fat pad weight mapped to 42 cM in both sexes (Gf2, LOD=7.14) and also in males (Gf4, LOD=4.43). Linkage to retroperitoneal fat pad weight mapped to 42 cM in both sexes (Rfpw3,LOD=7.38) and in males (Rfpw4, LOD=3.66), and mapped to 4 cM (Rfpw7, LOD=4.55) in females. Potential candidate genes include Cfd (Adipsin, 43 cM), Pmch (47 cM), Ppap2c (42 cM), and Gamt (43 cM).

Original:  J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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