Dmrtc2^tm1(cre)Knis
Targeted Allele Detail

Summary

• Symbol: Dmrtc2^tm1(cre)Knis
• Name: doublesex and mab-3 related transcription factor like family C2; targeted mutation 1, Katsuhiko Nishimori
• MGI ID: MGI:3697743
• Synonyms: Dmrt7^-, Dmrt7^tm1(cre)Knis
• Gene: Dmrtc2 Location: Chr7:24569482-24577076 bp, + strand Genetic Position: Chr7, 13.33 cM, cytoband A3
• Alliance: Dmrtc2^tm1(cre)Knis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117721
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Dmrtc2^tm1(cre)Knis expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dmrtc2 (MGI:1918491)

• Mutation details: Exons 2 and 3 were replaced with cre recombinase and a neomycin resistance cassette in-frame. Northern blot confirmed absence of transcript in mutant testes. (J:117721)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dmrtc2 (mouse) Summary of all recombinase alleles driven by Dmrtc2. Alliance mouse Dmrtc2 gene page

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dmrtc2 Mutation: 13 strains or lines available

References

• Original: J:117721 Kawamata M, et al., Mice deficient in Dmrt7 show infertility with spermatogenic arrest at pachytene stage. FEBS Lett. 2006 Nov 27;580(27):6442-6
• All: 3 reference(s)