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Apba2tm1Sud
Targeted Allele Detail
Nomenclature
Symbol: Apba2tm1Sud
Name: amyloid beta (A4) precursor protein-binding, family A, member 2; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:3697709
Gene: Apba2  Location: Chr7:64151454-64403626 bp, + strand  Genetic Position: Chr7, 34.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:115573
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe exon encoding amino acids 368-416 of the phosphotyrosine binding (PTB) domain is flanked by loxP sites. A single FRT site, the remnant of an FRT-flanked neomycin resistance cassette (neo) previously removed by crossing mice with the cassette to mice expressing Flp recombinase in the germline, is present in the downstream intron. (Retention of the neo cassette ablates expression of this gene in mice.) Immunoblot analysis of brain homogenates demonstrates that mice with this conditional mutation express the protein at wild-type levels. (J:115573)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apba2 Mutation:  28 strains or lines available
References
Original:  J:115573 Ho A, et al., Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J Neurosci. 2006 Dec 13;26(50):13089-101
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory